Tinzaparin
26.07.2024
Tinzaparin
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For Prelims: About Tinzaparin, Highlights of the research |
Why in the news?
Researchers found tinzaparin significantly reduced damage to human cells due to spitting cobra venom.
About Tinzaparin:
- It is a drug used to treat serious blood clots, and can reduce damage to cells due to spitting cobra venom.
- It is a low-molecular-weight heparin (LMWH) with antithrombotic properties.
- It is used for the treatment of deep venous thrombosis, a condition in which harmful blood clots form in the blood vessels of the legs.
Highlights of the research
- Tanzaparin worked by blocking the interaction between the venom and its receptor in the cell by binding to venom molecules.
- Snake Venom’s toxicity depended on the biological pathway that synthesized heparan sulphate, artificially stopping this pathway could ameliorate the venom’s toxic effects.
- One way of doing so is to introduce molecules that closely resemble heparan sulphate. As the body senses an excess of these molecules, it shuts down the pathways responsible for heparan sulphate synthesis. One such molecule is tinzaparin.
- When the team introduced tinzaparin immediately after subjecting cells to the snake venom, the cells survived.
What is heparan sulphate?
- It is found on the surface of human and animal cells. Heparin sulfate is released from our cells when our immune systems respond to a threat.
Source: The Hindu
Ques :- Tinzaparin drug, recently in the news is used to treat:
A.Tuberculosis (TB)
B.Mpox
C.HIV
D.blood clots
Answer D